Strengths: interplay/relationship between Downey & Galifianakis, excellent comedic moments, Danny McBride, RZA as an airport screener, soundtrack that complements the film well (as opposed to The Hangover where most of the songs made no sense with the scenes)
Weaknesses: ridiculous/unbelievable premise, few surprises, some "I knew that was coming" moments, time vs. Juliette Lewis, Jamie Foxx's character is mostly pointless, functional but forgettable supporting cast
Verdict: If you don't bother to think too much (or perhaps at all) it's a thoroughly entertaining road comedy, just nothing original. The best reason to see it is for Downey vs. Galifianakis, especially if you're a fan of either/both of them.
6/10