62. Lizard

Dr. Curt Connors was once a skilled surgeon who enlisted in the army to help wounded GIs. After a blast injured his arm, it had to be amputated. When he got back to the states as a research technologist, he became obsessed with the secrets of reptiles and their limb regenerating abilities. Connors created an experimental serum from reptile DNA and made himself the guinea pig. His arm did grow back but not without side effects-the main one being turning into a giant human lizard.

As Lizard, Dr. Connors has superhuman strength, speed and agility. He can scale walls, regenerate limbs and whip his tail at high speeds. The Lizard can also mentally command all reptiles within a one-mile radius. What makes Lizard so hard to deal with is the man inside the monster. Peter Parker continually uses his own scientific prowess to change him back into his friend Curt Connors. But with stress or chemical reactions, he always seems to go back into remission. Even though he shows no love for humans, you can also still tell that Dr. Connors is inside there somewhere, as he never seems to harm his wife Martha or their son Billy. Aww.

As Connors, he's sacrificed turning back into Lizard to help Spider-Man many a time. He's saved Aunt May's life, developing a formula to dissolve the Rhino's costume and etc. all to later become the Lizard again since he had to deal with chemicals. He also let Parker be his teaching assistant at Empire State University for a time, and you know how unreliable Parker can be.